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Cordyceps militaris 1% or 5% cordycepin
Cordyceps militaris 1% or 5% cordycepin
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Energy | Athletic Performance | Libido Enhancer | Fertility Support
Buy Cordyceps militaris wholesale with the Mushroom Dispensary.
Note: Can be purchased as powders or made up in blends to personal specifications, and supplied in capsules or powders upon request.
All of our mushroom specimens and extracts are lab-tested, quality-controlled, and supplied by trusted growers on farms we have personally visited.
Summary
Summary
To date, over 700 species of Cordyceps have been identified worldwide, in most cases growing parasitically on their insect hosts. However, it has also been suggested that in some cases, a symbiotic relationship exists whereby the insect host derives a selective advantage from the fungal anamorph. Although traditionally harvested Cordyceps is still available, the vast majority of Cordyceps on the market today is cultivated on non-insect, grain-based substrates leading to improved quality control and affordability. Despite the commercially cultivated Cordyceps being grown on a different substrate from wild-collected Cordyceps, HPLC analysis shows identical chemical profiles and the two are seen to be interchangeable clinically ³. As well as polysaccharides and lipids, Cordyceps species contain a large number of nucleoside analogues. Chief among these is cordycepin, or 3-deoxyadenosine, which is found in high levels in C. militaris.
Recommended Medicinal Uses
Recommended Medicinal Uses
•Increasing endurance, energy output and oxygen capacity ¹⁶⁻²⁰
•Increasing levels of male sex hormones & improving sexual functionImproving sperm quantity and quality
•Beneficial for female fertility due to its ability to stimulate oestrogen productionPotential for the management of postmenopausal osteoporosis ²⁹
•Regulating immune functionOne of the most effective mushrooms for tackling chronic viral infections ⁹,¹⁰
•Treating diabetes due to triggering the release of insulin, increasing hepatic glucokinase, and sensitivity of cells to insulin
•Hepatoprotective & can aid in restoring liver function ³⁷⁻³⁹
•Improving kidney function in patients with chronic renal failure ³
•Improving treatment outcomes in cancerInducing apoptosis in multiple cancer cell lines including oral, colorectal, bladder, leukaemia, melanoma, multiple myeloma, breast and prostate ⁴¹⁻⁵²
Dose
Dose
Cordyceps’ unique properties are principally those of its nucleoside derivatives. As these are largely excreted (research on C. militaris shows that 98% of cordycepin is secreted into the growth medium ⁵³) mycelial biomass products offer the natural dosage format for Cordyceps. In most cases, 2-3g/day mycelial biomass is used, while higher levels have been reported to give good results with a range of cancers ². Some practitioners prefer to use C. militaris for cancer and viral infections due to its higher cordycepin levels ⁵⁴,⁵⁵.
Contraindications
Contraindications
Caution should be exercised when prescribing to patients with hormone-dependent cancers (prostate and breast) due to increased levels of oestrogen and testosterone. Although Cordyceps shows benefits for exercise and endurance, possible immune suppression mitigates against its use in immune-deficient conditions. We recommend that medical professionals prescribing Cordyceps militaris mushrooms check contraindications with patients’ medical history and active prescriptions.
Research
Research
1. Cordyceps fungi: natural products, pharmacological functions and developmental products. Zhou X, Gong Z, Su Y, Lin J, Tang K. J Pharm Pharmacol. 2009;61(3):279–291.
2. What is the Chinese caterpillar fungus Ophiocordyceps sinensis (Ophiocordycipitaceae)?. Shrestha B, Zhang WM, Zhang YJ, Liu XZ. Mycology. 2010;1(4):228–236.
3. Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes). A review. Holliday J, Cleaver MP. Int J Med Mushrooms. 2008;10(3):219–234.
4. Analysis of the main nucleosides in Cordyceps sinensis by LC/ESI-MS. Xie JW, Huang LF, Hu W, He YB, Wong KP. Molecules. 2010;15(1):305–314.
5. Measurement of cordycepin and adenosine in stroma of Cordyceps sp. by capillary zone electrophoresis (CZE). Ling YJ, Sun YJ, Zhang H, Lv P, Zhang CK. J Biosci Bioeng. 2002;94(4):371–374.
6. Chemical screening and identification of high cordycepin containing cultured isolate(s) of medicinal Chinese caterpillar mushroom, Ophiocordyceps sinensis (Berk.) G.H. Sung et al. Varshney VK, Pandey A, Kumar A, Rathod D, Kannojia P. Int J Med Mushrooms. 2011;13(4):327–333.
7. Chemical composition and nutritional and medicinal value of fruit bodies and submerged cultured mycelia of culinary-medicinal higher Basidiomycetes mushrooms. Cohen N, Cohen J, Asatiani MD, Varshney VK, Yu HT, Yang YC, Li YH, Mau JL, Wasser SP. Int J Med Mushrooms. 2014;16(3):273–291.
8. Some biologically active substances from a mycelial biomass of medicinal Caterpillar fungus Cordyceps sinensis (Berk.) Sacc. (Ascomycetes). Smirnov DA, Babitskaya VG, Puchkova TA, Shcherba VV, Bisko NA, Poyedinok NL. Int J Med Mushrooms. 2009;11(1):69–76.
9. Effect of cordycepin triphosphate on in vitro RNA synthesis by plant viral replicases. White JL, Dawson WO. J Virol. 1979;29(2):811–814.
10. Cordycepin interferes with 3’end formation in yeast independently of its potential to terminate RNA chain elongation. Holbein S, Wengi A, Decourty L, Freimoser FM, Jacquier A, Dichtl B. RNA. 2009;15(5):837–849.
11. Cordycepin (3′-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner. Cho HJ, Cho JY, Rhee MH, Park HJ. Eur J Pharmacol. 2007;558(1-3):43–51.
12. Immunosuppressive effect of Cordyceps CS-4 on human monocyte-derived dendritic cells in vitro. Tang J, Tian D, Liu G. Am J Chin Med. 2010;38(5):961–972.
13. Mycelium cultivation, chemical composition and antitumour activity of a Tolypocladium sp. fungus isolated from wild Cordyceps sinensis. Leung PH, Zhang QX, Wu JY. J Appl Microbiol. 2006;101(2):275–283.
14. Mckenna DJ, Jones K, Hughes K, Humphrey S: Botanical Medicines: The Desk Reference for Major Herbal Supplements. Second Edition. New York, NY: Abingdon: Routledge, 2012. p. 170.
15. Antiaging effect of Cordyceps sinensis extract. Ji DB, Ye J, Li CL, Wang YH, Zhao J, Cai SQ. Phytother Res. 2009;23(1):116–122.
16. Increased aerobic capacity in healthy elderly humans given a fermentation product of Cordyceps CS-4. Xiao Y, Huang XZ, Chen G, Wang MB, Zhu JS. Med Sci Sports Exerc. 1999;31(5):S174.
17. Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers. Xiao Y, Huang XZ, Zhu JS. Chin J Integr Med. 2004;10(3):187–192.
18. Effect of medicinal plant extracts on forced swimming capacity in mice. Jung K, Kim IH, Han D. J Ethnopharmacol. 2004;93(1):75–81.
19. CordyMax enhances aerobic capability, endurance performance, and exercise metabolism in healthy, mid-age to elderly sedentary humans. Zhu JS, Rippe JM. Chin J Gerontology. 2001;20:297–298.
20. Effect of Cs-4® (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. Chen S, Li ZP, Krochmal R, Abrazado M, Kim WS, Cooper CB. J Altern Complement Med. 2010;16(5):585–590.
21. Cordyceps sinensis supplementation does not improve endurance performance in competitive cyclists. Parcell AC, Smith JM, Schulthies SS, Myrer JW, Fellingham G. Med Sci Sports Exerc. 2002;34(5):S231.
22. Does Cordyceps sinensis ingestion aid athletic performance? Walker TB. Strength Cond J. 2006;28(2):21–23.
23. Effect of Cordyceps militaris supplementation on sperm production, sperm motility and hormones in Sprague-Dawley rats. Chang Y, Jeng KC, Huang KF, Lee YC, Hou CW, Chen KH, Cheng FY, Liao JW, Chen YS. Am J Chin Med. 2008;36(5):849–859.
24. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Hsu CC, Huang YL, Tsai SJ, Sheu CC, Huang BM. Life Sci. 2003;73(16):2127–2136.
25. Influence of Cordyceps sinensis on reproduction and testis morphology in mice. Jin HL, Guo RX. Shenzhen J Integr Tradit Chin West Med. 2006;16(5):289–292.
26. Improvement of sperm production in subfertile boars by Cordyceps militaris supplement. Lin WH, Tsai MT, Chen YS, Hou RC, Hung HF, Li CH, Wang HK, Lai MN, Jeng KC. Am J Chin Med. 2007;35(4):631–641.
27. Estrogenic substances from the mycelia of medicinal fungus Cordyceps ophioglossoides (Ehrh.) Fr. (Ascomycetes). Kawagishi H, Okamura K, Kobayashi F, Kinjo N. Int J Med Mushrooms. 2004;6(3):249–252.
28. Upregulation of steroidogenic enzymes and ovarian 17β-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Huang BM, Hsiao KY, Chuang PC, Wu MH, Pan HA, Tsai SJ. Biol Reprod. 2004;70(5):1358–1364.
29. The co-effect of Cordyceps sinensis and Strontium on osteoporosis in ovariectomized osteopenic rats. Qi W, Yan YB, Wang PJ, Lei W. Biol Trace Elem Res. 2011;141(1-3):216–223.
30. Polysaccharides in fungi XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver. Kiho T, Yamane A, Hui J, Usui S, Ukai S. Biol Pharm Bull. 1996;19(2):294–296.
31. Structural features and hypoglycemic activity of a polysaccharide (CS-F10) from the cultured mycelium of Cordyceps sinensis. Kiho T, Ookubo K, Usui S, Ukai S, Hirano K. Biol Pharm Bull. 1999;22(9):966–970.
32. Anti-hyperglycemic activity of natural and fermented in rats with diabetes induced by nicotinamide and streptozotocin. Lo HC, Hsu TH, Tu ST, Lin KC. Am J Chin Med. 2006;34(5):819–832.
33. Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia. Li SP, Zhang GH, Zeng Q, Huang ZG, Wang YT, Dong TT, Tsim KW. Phytomedicine. 2006;13(6):428–433.
34. Cordycepin suppresses expression of diabetes regulating genes by inhibition of lipopolysaccharide-induced inflammation in macrophages. Shin S, Lee S, Kwon J, Moon S, Lee S, Lee CK, Cho K, Ha NJ, Kim K. Immune Netw. 2009;9(3):98–105.
35. Aqueous extracts of Cordyceps militaris (Ascomycetes) lower the levels of plasma glucose by activating the cholinergic nerve in Streptozotocin-induced diabetic rats. Cheng YW, Chen YI, Tzeng CY, Chang CH, Lee YC, Chen HC, Tsai CC, Hsu TH, Lai YK, Chang SL. Int J Med Mushrooms. 2013;15(3):277–286.
36. Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats. Dong Y, Jing T, Meng Q, Liu C, Hu S, Ma Y, Liu Y, Lu J, Cheng Y, Wang D, Teng L. Biomed Res Int. 2014:2014:160980.
37. Inhibitive effect of Cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism. Liu YK, Shen W. World J Gastroenterol. 2003;9(3):529–533.
38. Dynamical influence of Cordyceps sinensis on the activity of hepatic insulinase of experimental liver cirrhosis. Zhang X, Liu YK, Shen W, Shen DM. Hepatobiliary Pancreat Dis Int. 2004;3(1):99–101.
39. Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice. Choi HN, Jang YH, Kim MJ, Seo MJ, Kang BW, Jeong YK, Kim JI. Nutr Res Pract. 2014;8(2):172–176.
40. Cordyceps sinensis supplementation as immunonutrition in alcohol induced liver steatosis-II. Santos C. Mycology News. 2004;1(9):2–6.
41. RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells. Chen LS, Stellrecht CM, Gandhi V. Br J Haematol. 2008;140(6):682–691.
42. Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. Wong YY, Moon A, Duffin R, Barthet-Barateig A, Meijer HA, Clemens MJ, de Moor CH. J Biol Chem. 2010;285(4):2610–2621.
43. Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cells. Zhou X, Meyer CU, Schmidtke P, Zepp F. Eur J Pharmacol. 2002;453(2-3):309–317.
44. Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells. Lee EJ, Kim WJ, Moon SK. Phytother Res. 2010;24(12):1755–1761.
45. Role of Cordycepin and Adenosine on the phenotypic switch of macrophages via induced anti-inflammatory cytokines. Shin S, Moon S, ParkY, Kwon J, Lee S, Lee CK, Cho K, Ha NJ, Kim
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