mushroom dispensary
Lentinus edodes | Xiang Gu | Shiitake
Lentinus edodes | Xiang Gu | Shiitake
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Immune Support | Cholesterol Control | Antiviral
Shop Shiitake mushroom powder wholesale with the Mushroom Dispensary.
Note: Can be purchased as powders or made up in blends to personal specifications, and supplied in capsules or powders upon request.
All of our mushroom specimens and extracts are lab-tested, quality-controlled, and supplied by trusted growers on farms we have personally visited.
Summary
Summary
Known for growing on decaying deciduous trees in Southeast Asia, Shiitake is often found on chestnut, oak, maple, beech, sweetgum, poplar, hornbeam and ironwood trees. Lentinus edodes is an important ingredient in Asian cuisine, and its annual production of roughly 2 million tonnes is second only to the common button mushroom, Agaricus bisporus. As well as being delicious, it has an excellent nutritional profile with high levels of B vitamins and pro-vitamin D2 (ergosterol) ¹. L. edodes Lentinan, a highly purified polysaccharide from L. edodes, is licensed in Japan for the treatment of gastric cancer. As well as being proven to slow the growth of cancer, L. edodes is also great for heart and general health. This is because it contains eritadenine, a compound known to reduce cholesterol levels in the blood, especially as an adjunct to statins.
Recommended Medicinal Uses
Recommended Medicinal Uses
• Offers a significant advantage over chemotherapy in terms of survival for patients with advanced gastric cancer ⁴
• Reduces chemotherapy side effects for patients with colorectal, hepatocelluar, oesophageal, breast cancer and metastatic prostate cancer ⁵,⁶
• Effective in decreasing cholesterol ¹,¹⁷,¹⁸
• Shown to have broad anti-viral and hepatoprotective properties ¹⁹⁻²⁰
• High levels of antimicrobial activity, including the highest anti-candidal action among several mushroom species
Dose
Dose
2-6g/day polysaccharide extract for immune support. 9g/day dried fruit body for cholesterol control. Since eritadenine’s cholesterol-lowering action differs from that of prescription statins or natural sources of statins such as Pleurotus ostreatus or Monascus purpureus, it can be combined with them in cholesterol control protocols.
Contraindications
Contraindications
Although there have been several reports of dermatitis (Shiitake Dermatitis) developing following consumption of L. edodes, these have been related to consumption of the raw mushroom. No such cases have been reported for the use of L. edodes in supplement form ²¹⁻²⁶. We recommend that medical professionals prescribing Shiitake check contraindications with patients’ medical history and active prescriptions.
Research
Research
1. Shiitake (Lentinus edodes). Wasser SP. In: Encyclopedia of Dietary Supplements. New York : Marcel Dekker, 2005. pp. 653–664.
2. Nationwide survey on complementary and alternative medicine in cancer patients in Japan. Hyodo I, Amano N, Eguchi K, Narabayashi M, Imanishi J, Hirai M, Nakano T, Takashima S. J Clin Oncol. 2005;23(12):2645–2654.
3. Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immuno-deficiency virus-1 reverse transcriptase and proliferation of leukaemia cells. Ngai PH, Ng TB. Life Sci. 2003;73(26):3363–3374.
4. Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer. Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J. Anticancer Res. 2009;29(7):2739–2745.
5. Effects of lentinan in advanced or recurrent cases of gastric, colorectal, and breast cancer. Taguchi T. Gan To Kagaku Ryoho. 1983;10(2 Pt 2):387–393.
6. Combination therapy with lentinan improves outcomes in patients with esophageal carcinoma. Wang JL, Bi Z, Zou JW, Gu XM. Mol Med Rep. 2012;5(3):745–748.
7. Effect of lentinan for advanced prostate carcinoma. Tari K, Satake I, Nakagomi K, Ozawa K, Oowada F, HigashiY, Negishi T, Yamada T, Saito H, Yoshida K. Hinyokika Kiyo. 1994;40(2):119–123.
8. Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes). Ng ML, Yap AT. J Altern Complement Med. 2002;8(5):581–589.
9. The medicinal benefits of Lentinan (β-1, 3-D glucan) from Lentinus edodes (Berk.) singer (Shiitake Mushroom) through oral administration. Yap AT, Ng MH. Int J Med Mushrooms. 2005;7(12):175–192.
10. Immunomodulatory and anticancer effects of active hemicellulose compound (AHCC). Ghoneum MH, Wimbley M, Salem FB, McKlain A, Atallah N, Gill G. Int J Immunotherapy. 1995;11(1):23–28.
11. Prognostic improvement of patients with advanced liver cancer after active hexose correlated compound (AHCC) treatment. Cowawintaweewat S, Manoromana S, Sriplung H, Khuhaprema T, Tongtawe P, Tapchaisri P, Chaicumpa W. Asian Pac J Allergy Immunol. 2006;24(1):33–45.
12. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Gao Y, Zhang D, Sun B, Fujii H, Kosuna K, Yin Z. Cancer Immunol Immunother. 2006;55(10):1258–1266.
13. Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer. Turner J, Chaudhary U. Anticancer Drugs. 2009;20(3):215–216.
14. An evidence-based review of a Lentinula edodes mushroom extract as complementary therapy in the surgical oncology patient. Shah SK, Walker PA, Moore-Olufemi SD, Sundaresan A, Kulkarni AD, Andrassy RJ. JPEN J Parenter Enteral Nutr. 2011;35(4):449–458.
15. Effect of active hexose-correlated compound in women receiving adjuvant chemotherapy for breast cancer: a retrospective study. Hangai S, Iwase S, Kawaguchi T, Kogure Y, Miyaji T, Matsunaga T, Nagumo Y, Yamaguchi T. J Altern Complement Med. 2013;19(11):905–910.
16. Reduction of adverse effects by a mushroom product, active hexose correlated compound (AHCC) in patients with advanced cancer during chemotherapy – the significance of the levels of HHV-6 DNA in saliva as a surrogate biomarker during chemotherapy. Ito T, Urushima H, Sakaue M, Yukawa S, Honda H, Hirai K, Igura T, Hayashi N, Maeda K, Kitagawa T, Kondo K. Nutr Cancer. 2014;66(3):377–382.
17. Production of the bioactive compound eritadenine by submerged cultivation of shiitake (Lentinus edodes) mycelia. Enman J, Hodge D, Berglund KA, Rova U. J Agric Food Chem. 2008;56(8):2609–2612.
18. Quantification of the bioactive compound eritadenine in selected strains of shiitake mushroom (Lentinus edodes). Enman J, Rova U, Berglund KA. J Agric Food Chem. 2007;55(4):1177–1180.
19. Polysaccharide and extracts from Lentinula edodes: structural features and antiviral activity. Rincão VP, Yamamoto KA, Ricardo NM, Soares SA, Meirelles LD, Nozawa C, Linhares RE. Virol J. 2012;9:37.
20. Shiitake, Lentinus edodes: Functional properties for medicinal and food purposes. Mizuno T. Food Rev Int. 1995;11(1):109–128.
21. Shiitake dermatitis: flagellate dermatitis after eating mushrooms. Haas N, Vogt R, Sterry W. Hautarzt. 2001;52(2):132–135.
22. Systemic allergic contact dermatitis due to consumption of raw shiitake mushroom. Kopp T, Mastan P, Mothes N, Tzaneva S, Stingl G, Tanew A. Clin Exp Dermatol. 2009;34(8):e910–913.
23. Shiitake dermatitis now occurs in France. Hérault M, Waton J, Bursztejn AC, Schmutz JL, Barbaud A. Ann Dermatol Venereol. 2010;137(4):290–293.
24. Shiitake dermatitis: a report of 3 cases and review of the literature. Chu EY, Anand D, Dawn A, Elenitsas R, Adler DJ. Cutis. 2013;91(6):287–290.
25. Shiitake Dermatitis – Now Also in Poland. Baran W, Batycka-Baran A, Maj J, Szepietowski JC. Acta Derm Venereol. 2015;95(1):102–103.
26. Shiitake dermatitis: toxic or allergic reaction? Corazza M, Zauli S, Ricci M, Borghi A, Pedriali M, Mantovani L, Virgili A. J Eur Acad Dermatol Venereol. 2015;29(7):1449–1451.
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