mushroom dispensary
Maitake | Grifola frondosa | Hen of the Woods
Maitake | Grifola frondosa | Hen of the Woods
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Hormonal Health | Immune Support | Fertility Aid
Buy Maitake wholesale with the Mushroom Dispensary.
Note: Can be purchased as powders or made up in blends to personal specifications, and supplied in capsules or powders upon request.
All of our mushroom specimens and extracts are lab-tested, quality-controlled, and supplied by trusted growers on farms we have personally visited.
Summary
Summary
A popular gourmet mushroom, Grifola frondosa is also highly regarded clinically, especially in cancer therapy. Also known as ‘Hen of the Woods’, this specimen grows at the base of trees, particularly oaks, and maples, from late summer to early autumn across China, Europe, and North America. As with other major anti-cancer mushrooms such as Lentinula edodes (Shiitake) and Trametes versicolor (Coriolus), polysaccharides are the major active components of G. frondosa and several beta-glucan, heteropolysaccharide, and proteoglycan fractions have been isolated with potent immunomodulatory action, including D-fraction and MD-fraction ¹⁻⁵.
Maitake can help with fertility, immune health, and restoring hormonal balance by regulating progesterone and improving insulin sensitivity, which is a key symptom for women suffering from conditions such as PCOS. It can also be used for bone health as it is known to stimulate osteoblasts, as well as increasing alkaline phosphatase, and supporting bone mineralization.
Recommended Medicinal Uses
Recommended Medicinal Uses
• Alleviating side effects and increasing the benefit of chemotherapy in a range of cancers ², ⁶⁻⁷
• Controlling blood sugar levels in diabetics ³, ⁸⁻¹⁰
• Improving symptoms of Polycystic Ovary Syndrome (PCOS) ¹¹⁻¹²
• Potential benefits for reducing cholesterol ¹³
• Short-lived hypotensive action¹⁴⁻¹⁶
Dose
Dose
The optimum dose of D-fraction/MD-fraction in animal studies is reported to be 1mg/kg i.p. with human trials using D-fraction/MD-fraction at oral doses of 35-150mg/day in combination with 4-6g/day G. frondosa fruiting body.
Contraindications
Contraindications
Maitake mushrooms could lower blood pressure especially when taken with some medications. We recommend that medical professionals prescribing Maitake check contraindications with patients’ medical history and active prescriptions.
Research
Research
1. Shiitake (Lentinus edodes). Wasser SP. In: Encyclopedia of Dietary Supplements. New York : Marcel Dekker, 2005. pp. 653–664.
2. Nationwide survey on complementary and alternative medicine in cancer patients in Japan. Hyodo I, Amano N, Eguchi K, Narabayashi M, Imanishi J, Hirai M, Nakano T, Takashima S. J Clin Oncol. 2005;23(12):2645–2654.
3. Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immuno-deficiency virus-1 reverse transcriptase and proliferation of leukaemia cells. Ngai PH, Ng TB. Life Sci. 2003;73(26):3363–3374.
4. Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer. Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J. Anticancer Res. 2009;29(7):2739–2745.
5. Effects of lentinan in advanced or recurrent cases of gastric, colorectal, and breast cancer. Taguchi T. Gan To Kagaku Ryoho. 1983;10(2 Pt 2):387–393.
6. Combination therapy with lentinan improves outcomes in patients with esophageal carcinoma. Wang JL, Bi Z, Zou JW, Gu XM. Mol Med Rep. 2012;5(3):745–748.
7. Effect of lentinan for advanced prostate carcinoma. Tari K, Satake I, Nakagomi K, Ozawa K, Oowada F, HigashiY, Negishi T, Yamada T, Saito H, Yoshida K. Hinyokika Kiyo. 1994;40(2):119–123.
8. Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes). Ng ML, Yap AT. J Altern Complement Med. 2002;8(5):581–589.
9. The medicinal benefits of Lentinan (β-1, 3-D glucan) from Lentinus edodes (Berk.) singer (Shiitake Mushroom) through oral administration. Yap AT, Ng MH. Int J Med Mushrooms. 2005;7(12):175–192.
10. Immunomodulatory and anticancer effects of active hemicellulose compound (AHCC). Ghoneum MH, Wimbley M, Salem FB, McKlain A, Atallah N, Gill G. Int J Immunotherapy. 1995;11(1):23–28.
11. Prognostic improvement of patients with advanced liver cancer after active hexose correlated compound (AHCC) treatment. Cowawintaweewat S, Manoromana S, Sriplung H, Khuhaprema T, Tongtawe P, Tapchaisri P, Chaicumpa W. Asian Pac J Allergy Immunol. 2006;24(1):33–45.
12. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Gao Y, Zhang D, Sun B, Fujii H, Kosuna K, Yin Z. Cancer Immunol Immunother. 2006;55(10):1258–1266.
13. Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer. Turner J, Chaudhary U. Anticancer Drugs. 2009;20(3):215–216.
14. An evidence-based review of a Lentinula edodes mushroom extract as complementary therapy in the surgical oncology patient. Shah SK, Walker PA, Moore-Olufemi SD, Sundaresan A, Kulkarni AD, Andrassy RJ. JPEN J Parenter Enteral Nutr. 2011;35(4):449–458.
15. Effect of active hexose-correlated compound in women receiving adjuvant chemotherapy for breast cancer: a retrospective study. Hangai S, Iwase S, Kawaguchi T, Kogure Y, Miyaji T, Matsunaga T, Nagumo Y, Yamaguchi T. J Altern Complement Med. 2013;19(11):905–910.
16. Reduction of adverse effects by a mushroom product, active hexose correlated compound (AHCC) in patients with advanced cancer during chemotherapy – the significance of the levels of HHV-6 DNA in saliva as a surrogate biomarker during chemotherapy. Ito T, Urushima H, Sakaue M, Yukawa S, Honda H, Hirai K, Igura T, Hayashi N, Maeda K, Kitagawa T, Kondo K. Nutr Cancer. 2014;66(3):377–382.
17. Production of the bioactive compound eritadenine by submerged cultivation of shiitake (Lentinus edodes) mycelia. Enman J, Hodge D, Berglund KA, Rova U. J Agric Food Chem. 2008;56(8):2609–2612.
18. Quantification of the bioactive compound eritadenine in selected strains of shiitake mushroom (Lentinus edodes). Enman J, Rova U, Berglund KA. J Agric Food Chem. 2007;55(4):1177–1180.
19. Polysaccharide and extracts from Lentinula edodes: structural features and antiviral activity. Rincão VP, Yamamoto KA, Ricardo NM, Soares SA, Meirelles LD, Nozawa C, Linhares RE. Virol J. 2012;9:37.
20. Shiitake, Lentinus edodes: Functional properties for medicinal and food purposes. Mizuno T. Food Rev Int. 1995;11(1):109–128.
21. Shiitake dermatitis: flagellate dermatitis after eating mushrooms. Haas N, Vogt R, Sterry W. Hautarzt. 2001;52(2):132–135.
22. Systemic allergic contact dermatitis due to consumption of raw shiitake mushroom. Kopp T, Mastan P, Mothes N, Tzaneva S, Stingl G, Tanew A. Clin Exp Dermatol. 2009;34(8):e910–913.
23. Shiitake dermatitis now occurs in France. Hérault M, Waton J, Bursztejn AC, Schmutz JL, Barbaud A. Ann Dermatol Venereol. 2010;137(4):290–293.
24. Shiitake dermatitis: a report of 3 cases and review of the literature. Chu EY, Anand D, Dawn A, Elenitsas R, Adler DJ. Cutis. 2013;91(6):287–290.
25. Shiitake Dermatitis – Now Also in Poland. Baran W, Batycka-Baran A, Maj J, Szepietowski JC. Acta Derm Venereol. 2015;95(1):102–103.
26. Shiitake dermatitis: toxic or allergic reaction? Corazza M, Zauli S, Ricci M, Borghi A, Pedriali M, Mantovani L, Virgili A. J Eur Acad Dermatol Venereol. 2015;29(7):1449–1451.
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